The wobble pairing , literally wobbly pairing , is a mode of not-canonical pairing between nucleotidic bases. One finds in particular even bases G-U, I-U/I-A/I-C which can play a big role in the secondary structure of ARN S. They differ from the Watson-Crick pairs by the nature of the bases and the hydrogen bonds implied.

Pairings wobble play a very important part in the translation of the genetic Code. They indeed make it possible to partly mitigate the disparity between the number of Codon S (64) and the number D “amino-acid (20), by using pairing wobbly or wobble with the first position of the Anticodon of the ARNt, which makes it possible same ARNt to recognize several code synonymous.

The Inosine (symbol I), bases modified that one frequently finds in first position of the anticodon of ARNt, is particularly important, because it allows pairings with U, has and C. pair G-U is also particularly frequent in many structures of ARN.

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