The syndrome of the central incisor single jawbone median is a complex syndrome affecting the embryonic development and beginning between the 36 éme day and the 38 éme day from the design. It results primarily in anomalies of the line of centers.

The Incisive S precisely develop and make their eruption on the level of the line of centers of the dental arch jawbone. Malformations of the nose are frequently associated. The presence of a syndrome of the central incisor single jawbone median can be it pilot of a holoprosencéphalie.

The other clinical signs are: a intellectual delay, cardiac malformations, labial and palatine slits and less frequently a microcephalus, characteristics facial, anomalies of digestive tract, tumors cervical, genital and renal anomalies. A small size is found in half of the children.

Sources

• Roger K Hall, Solitary median maxillary central incisor (SMMCI) syndrome in Orphanet Newspaper off Rare Diseases 2006,1:12 (9 April 2006) DOI: 10.1186/1750-1172-1-12