The syndrome of Werner results in a premature ageing associated with a predisposition to the Cancer S. the development is normal until the 10 years age. The first sign is the stop of teeth. Around 20 years, the hair bleaches and becomes rare, the voice loses its force and the skin changes. A bilateral cataract appears with diabetes, Ostéoporose and ulcerates cutaneous and hypogonadism.
The myocardial infarction or cancer is the main causes of death, generally before 50 years.

The syndrome of Werner must be distinguished from the Progeria, which is always due to a change.

Description

• premature bleaching of the hair
• Nanisme
• Hypogonadisme
• Cataracte
• atrophies pseudo-sclérodermique lower extremities
• abnormally high incidence of malignant tumors

Sources

• Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MANDELEVIUM. MIM Number: 277700 * Nancy Hanson, George Mr. Martin, Junko Oshima, Werner Syndrome In GeneTests: Medical Genetics Information Resource (database online). Copyright, University off Washington, Seattle. 1993-2005 ===Références===