Syndrome of Goodpasture

The pneumo-renal syndrome of Goodpasture or disease of the glomerular antibody basal anti-membrane is a very rare disease of auto-immune origin associating a pulmonary hemorrhage, a glomerulonephritis extracapillaire, and antibodies directed against the renal and alveolar membranes basal glomerular pulmonary.

  • the syndrome pneumorénal of Goodpasture is related to the tissue toxicity of antibody basal anti-membranes. The lesions are primarily on the level of the air cells and the renal clusters.

  • There exists a hemorrhagic alveolite with dyspnea, hémoptysies, acute respiratory insufficiency.
  • There exists also a Glomérulonéphrite proliferative necrosing with possibility of extra proliferation capillary. One sees hématuries, a arterial Hypertension and a oligo- Anurie.
  • the treatment is based on the plasmatic exchanges (Plasmaphérèse) the injections of Immunoglobuline S with strong amount, the corticothérapie and the Immunosuppresseur S.

External bonds

  • Orphanet
  • References practices 1999, GERM' O' P.

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