Streptomycine

The streptomycine is a Antibiotique antibactérien cytostatic and cytotoxic. It belongs to the class of the Aminoside S (or aminoglycosides). It is besides the first member of this class to have been discovered (in 1943). It was isolated starting from a stock from actinobactery Streptomyces griseus . The discovery was the work of the student Albert Schatz but the merit flashes back on its Professor, Selman Abraham Waksman, which obtained the Nobel Prize of medicine in 1952.

Mode of action

The antibiotics of this class act by setting on a structure intrabactérienne called Ribosome (precisely on the sub-unit 30S in the case of the streptomycine). Once the antibiotic fixed on ribosome, the Bactérie produces Protéine S not functional calculuses and dies quickly. It is managed by intramuscular injection.

Spectrum of action and resistances

The spectrum of action of the streptomycine is rather broad since it can act on some bacilli negative Gram S (like Escherichia coli ) or some Cocci positive Gram S (like the Staphylococcus aureus ). This antibiotic also acts on Mycobacterium tuberculosis , and was besides the first antibiotic against the Tuberculose. Nevertheless, of many pseudo stocks of these bacteria in the beginning sensitive to the streptomycine developed a Résistance to the antibiotics (for example by producing enzymes degrading antibiotic).

Side effects and counter-indications

This antibiotic is disadvised at the expectant mother. Like any drug, it can show undesirable side effects (in particular renal and auditive disorders ).

Code ATC

• J01GA01