The scleroderma is a Maladie which, in its located form, causes anomalies of the Peau.

In generalized form (systemic), it attacks many bodies and in particular the heart (coronaropathy) and the kidney (vascular nephropathy).
Noncontagious, this disease car immune can be contracted at any age. Scleroderma reaches 3 women for 1 man and is usually declared between 30 and 50 years.
It is generally preceded by benign conjunctive disorders. Difficult to diagnose, it can spend several years to be declared.
The systemic form brings into play the vital prognosis, because no effective cure currently exists. The evocative clinical signs are the symptoms evoking a Syndrome from CREST to knowing Calcinose subcutaneous, phenomenon of Raynaud (change of coloring of the interrupters with the cold), disorders of the motility oesophagienne with dysphagie, Sclérodactylie and Télangiectasies.

Biology finds usually antinuclear antibodies and, in a more specific but less frequent way, anti-Scl70 antibodies.

It is advisable to seek in the forms atypical or quickly progressive a subjacent neoplasy.

Treatment

The treatments which were proposed are corticoids, the immunosuppresseurs (Cyclophosphamide: ENDOXAN or Azathioprine: IMUREL) and treatment of a possible neoplasy sous-jacente.
Currently, the prostaglandins (iloprost: ILOMEDINE) are proposed for their vasodilator effects which allows sometimes an significant improvement.
The Corticoids and the Anti-inflammatoire not stéroïdien (AINS) act on the especially articular painful component; the cutaneous topics are proposed to relieve and invigorate the skin.

External bonds

• French Group of Research on Scleroderma (GFRS)
• the Company of arthritis: Company of research financed by the laboratory '' Pfizer Canada Inc ''.
• CHU Rouen
• Association of the Sclérodermiques Patients of Belgium

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