Sévoflurane

The sévoflurane is a volatile Anesthetic agent of the family of the ethers halogenous S used for the induction and the maintenance of the general anesthesias. Its good clinical tolerance and its pharmacological behavior allowing a fast alarm clock gradually made it prefer, with the Desflurane, with the older molecules (Halothane, Enflurane and Isoflurane) in the Western countries.

History

The sévoflurane is most recent of anesthetic halogenous: it was used for the first time at the Japan in 1990.

Properties

The mode of action of the sévoflurane remains partially unknown. Managed with the mask thanks to an anesthetic spray, it is generally associated with the Protoxyde of nitrogen and the Oxygène. Its soft odor authorizes its administration for the induction of the anesthesia, which makes of him the modern agent of choice for the anesthesia of the children, or even of the adults (pusillanimity, reduced venous capital…). Its CAMWOOD is of 2% vol. Its cost high is the main obstacle with its generalization: the Isoflurane is still often preferred to him for economic reasons.

Undesirable effects

The tolerance of the sévoflurane is overall very good. As all the halogenous gases the sévoflurane support a arterial Hypotension per-operational and increase the risk of nauseas and post-operative vomiting. To date hepatic toxicity or renal of the sévoflurane at the man seems almost non-existent. It is likely, at the predisposed subjects, to start a malignant crisis of Hyperthermie.

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