Repertory of pharmacology

Repertory of the Pharmacology

Cardiovascular system

Drugs of cardiac failure

Glycosides digitalic

the Digoxine does not have any more that one place limited in the assumption of responsibility of the patients reached of Cardiac failure, but it is sometimes used in the auricular Fibrillation to slow down the ventricular answer.
the Digitoxine has the same narrow therapeutic coefficient as the digoxine and, for purpose equal Inotrope, they have the same probability of involving undesirable effects. They differ however by their properties Pharmacocinétique (36 hours for the digoxine when the renal function is normal, 6 days for the digitoxine). There does not exist currently any more speciality containing digitoxine on the Belgian market.
the Métildigoxine probably has the same properties, undesirable effects and interactions that the digoxine. Since the experiment with the digoxine is much larger, the use of métildigoxine is not justified.

Indications

Auricular fibrillation (to slow down a fast ventricular rate/rhythm or in the event of symptomatic cardiac failure).

Counter-indications

auriculo-ventricular Block (especially with 2nd or 3rd degree).
Cardiomyopathie obstructive
Syndrome of Wolf-Parkinson-White.

Undesirable effects

turbid Nauseas and others gastro-intestinal.
Arrhythmia S (Extrasystole S ventricular, auricular Tachycardia with block AV = auriculo-ventricular).
neurological Demonstrations (p. e.g. tires, eye trouble).
Increased risk of undesirable effects in the event of Hypokaliémie.

Special precautions

For the digoxine, the resorption is incomplete and variable : the differences in resorption can be due to the galenic form or interactions.
the margin therapeutic-poison is narrow . The determination of the plasmatic concentrations of the digoxine (classically between 1 and 2 ng/ml, but less in the elderly) can be indicated. In study DIG carried out among patients reached of cardiac failure and a major reduction in the left ventricular function, an increased mortality was observed with concentrations of digoxine higher than 1,2 ng/ml.
It is necessary to take account of the renal function (especially for the digoxine) . The majority of the cases of toxicity are due to too high amounts, p. e.g. when one does not take account of factors such as the age or an impaired renal function.
In the event of severe intoxication, the administration of antibody antidigoxine can be indicated.

Interactions

Antiangoreux

Antiarythmiques

Antihypertenseurs

Diurétiques

Drugs of hypotension

Drugs of the vascular disorders

Substances veinotropes and cappillarotropes

Drugs antithrombotic

Antihémorragiques

Hypolipémiants

Gastro-intestinal system

Drugs of gastric pathology and duodénale

Spasmolytic

Drugs for the liver, the blister and the pancreas

Antiémétiques

Laxatives

Antidiarrhéiques

Drugs of the inflammatory affections of the intestine

Intestinal disinfectants

Drugs against the hémorroïdes

Urogenital system

Drugs used in the vesical problems

Drugs used in the benign hypertrophy of the prostate

Drugs used in the impotence

Others

Respiratory system

Drugs in asthma and the BPCO

Cough mixtures, mucolytic and expectorants

Analeptiques respiratory

Drugs of the rhinitides and sinusitises

Pain and ignition

Analgesics - antipyretic

Anti-inflammatory drugs not stéroïdiens

Various substances used in ostéo-articular pathologies

Morphine analgesics

Morphine antagonists

Control pain in palliative care

Nervous system

Hypnotic, sedative, anxiolytic

Antipsychotic

Antidepressants

Central stimulants

Antiparkinsonniens

Antiépileptiques

Antimigraineux

H1 antihistamines

Inhibiters of the cholinestérases

Drugs of the disease of Alzheimer

Hormonal system

Glucocorticoïdes

Drugs of the thyroid one

Sex hormones

Drugs of the diabetes

Other drugs of the hormonal system

Infections

Antibactériens

Antimycosiques

Pesticides

Antiviral

Immunity

Vaccines, immunoglobulins and serums

Immunomodulateurs and immunosuppresseurs

Antitumor drugs

Agents alkylants

Antimétabolites

Antitumor antibiotics

Inhibiters of topo-isomérase

Inhibiters of the microtubules

Monoclonal antibodies

Antitumor various

Minerals, vitamins and tonics

Minerals

Vitamins

Tonics

External use

Drugs of dermatological use

Drugs of ophthalmic use

Drugs of otic use

Drugs of the bucco-pharyngées affections

Drugs of the vulvo-vaginal affections

Anesthetic buildings

Agents of diagnosis

Agents of radiodiagnosis

Agents of diagnosis by magnetic resonance

Other agents of diagnosis

Various drugs

Drugs used in obesity

Drugs used in alcoholism

Drugs used in the nicotinism

Drugs of the spastic states

Drugs used like desensitizing

Drugs acting on the uterine musculature

Drugs used in anesthesia

Drugs used in the hyperkaliemy

Diphosphonates

Strontium Ranélate

Drugs used in enzymatic deficits

Chelating of phosphate

Alprostadil

Bosentan

Cholinomimétiques

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