Receiver metabotropic

The receiving métabotropes are Protéine S membrane which in answer to the action of a ligand change their conformation and activate a cascade of intracellular events. In general, the receivers métabotropes are coupled with Molécule S associated with the membrane called trimeric proteins G. The activation of the receiver involves the dissociation of the protein G which then will interact directly with a ionic Canal or will start an intracellular cascade of indication implying various effector proteins. Contrary to the receiving ionotropes, the receivers métabotropes do not contain ionic channels.

A long time comsidérés like specific of the animals, these receivers were also identified at the plants.

Structure

These proteins are made up of a chain with 7 transmembrane fields. The aminoterminale end is extracellular and constitutes with the extracellular loops the field of laison to the Ligand. The carboxyterminale end is cytosolic and is often implied in the regulation of the traffic, with the liking of the posttraductionnelles modifications (palmitoylation, phosphorylation…)

Some of these receivers, if not all, are present in the form of homo-oligomers or of hétéro-oligomers with other receivers métabotropes.

Classification and examples

likely to be improved

One knows many families of receivers métabotropes. They are classified according to the ligand which activates the receiver but also according to the size of the extracellular field. One distinguishes inter alia:

of the receivers métabotropes to the Glutamate
of the receivers métabotropes to the Acetylcholine; muscarinic receiving
of the receivers métabotropes to the Noradrenalin.
of the receivers métabotropes to the Serotonin.
of the receivers métabotropes to GABA, the receiving GABA_B.

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