Reaction of Kolbe
The reaction of Kolbe , called sometimes reaction of Kolbe-Schmitt , is an organic reaction of Carboxylation where the Phénolate of sodium (the salt of Sodium of the phenol) is initially treated with the Carbon dioxide under pressure (100 atmospheres) and with 125º, then with the sulphuric Acid . The finished product is a aromatic acid Hydroxy whose Salicylic acid (acid O hydroxybenzoic), precursor of the Aspirine, is a notable example. In the reaction, it is formed also the P-hydroxybenzoïque. The two isomers can be separated by Distillation with the vapor, the ortho being most volatile.
See too
- references of the english language version
- Morrison and Boyd - Organic chemistry ISBN 0-205-08452-4
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