Pilocarpine
Origin: The pilocarpine is a Alcaloïde extracted the sheets from Jaborandi ( Pilocarpus pennatifolius Lemaire or Pilocarpus microphyllus ), of the family of the Rutacée S. It is used like Parasympathicomimétique, causing for example a Myosis when it is used by way Oculaire.
One can use it as oral treatment of the Xérostomie Iatrogène, following Radiothérapie in the area of the neck.
Hydrochlorate of pilocarpine
List: 1
organoleptic Characters : needles, plates colorless, odorless, of bitter savor. Very water soluble and alcohol, insoluble in ether and soluble in only 555 chloroform p.
Properties : pilocarpine is an alkaloid with direct action, involving effects especially muscarinic, inter alia an increase in the secretion of salivary glands.
Myotique by constriction of the iridal Sphincter.
Complex cardiovascular action: parasympathomimetic effect (vasodilatation).
external bond: Clinical study:
Clinical study. The effectiveness and the safety of pilocarpine were shown by a study randomized as a double blind man, at 207 patients suffering from xerostomia caused by the radiotherapy.
With the amount of 15 Mg per day, in 3 catches, pilocarpine reduced or removes the dryness of the mouth and the difficulty in speaking.
Conservation : safe from the light and moisture.
Bibliography :
Dorvault
Base of Biam data:
HAS: high autorié of health
Clinical study:
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