Pancuronium
The pancuronium is a curare not depolarizing of the family of the amino Stéroïde S, marketed in the form of bromide of pancuronium (Pavulon ®). It is used like myorelaxant in General anesthesia and among patients of Réanimation.
Pharmacological effects
Antagonistic competitive of the Acetylcholine on the level of the driving Plate, the pancuronium induces a paralysis of the voluntary musculature into three to five minutes after an intravenous injection, allowing good conditions of Intubation trachéale and an essential muscular relaxation in certain surgeries (in particular abdominal). However, its very long life of action (100 minutes on average, with total recovery at the end of 120 to 180 minutes) practically made it give up in anesthesia (except for the interventions of long life requiring a complete muscular relaxation). There remains largely used by the réanimateurs, in particular because of his low costs.
Another use
The bromide of pancuronium is also one of the products used with the the United States during the executions by Lethal injection of condemned to death.
Antidote
The antidote of pancuronium (and all the curares not-depolarizers) is the Néostigmine. The Sugammadex could also be used in the near future.
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