Oxidation of Swern

The soft oxidation of the primary alcohols and secondaries in Aldehyde and Ketone in a medium containing of the Chloride oxalyl, the Diméthylsulfoxyde and the Triéthylamine is called reaction of Swern .

The principal advantage of this method lies in the softness of the conditions which compensates for the use of toxic reagents (oxalyl chloride, diméthylsulfoxyde, release of Carbon monoxide). It is of more impossible to observe additional oxidation in Carboxylic acid in the case of the oxidation of a primary education alcohol. This method is very often used in the total synthesis of natural products.

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