Naproxene

The naproxene is a AINS (anti-inflammatory drug not stéroidien) often used to treat the weak or moderated Douleur S, the Fièvre, the Inflammation and the arthralgies of certain pathologies the such Ostéoarthrite, the Arthrite rhumatoïde, the psoriatic Arthrite, the drop, the Spondylite ankylosante, the wounds, the menstrual pains, the Tendinite, the Bursite and the treatment of the primary Dysménorrhée.

The anti-inflammatory drugs not stéroidiens act by inhibiting an important enzyme in the mechanism of the ignition and the pain. (COX or cyclooxygénase). The naproxene is not specific, contrary to the new AINS which target the COX-2 specifically. Albumin and thus achieves has to skirt Half-life in the blood than other drugs, lasting up to 12 hours per amount. --> The naproxene is also available in the form of its sodic salt, the sodic naproxene , which is more quickly absorbed in the digestive Tract.

The naproxene appeared Naprosyn -->en 1976 ; sodic naproxene in 1980.

Structure and details

Within the AINS, the naproxene belongs to the family of derived from the arylacetic Acide. It is an odorless, white crystalline substance or blanchâtre. Its Molecular weight is of 230,2628. The naproxene is liposoluble, practiquement insoluble in water with weak a pH (lower than pH 4), but rather water soluble of pH equal to or higher than 6. The naproxene has a Point melting of 153 °C.

Side effects and precautions

The nonspecific AINS have many side effects. They inhibit the COX-1, enzyme essential with the level of gastric protection. It is thus not rare that the patients feel brûlements of stomach (backward flow gastro-oesophagien) and can even see themselves reached of a secondary ulcer of stomach to the catch of the AINS.

In addition, they have also many effects on the renal metabolism. Indeed, from their inhibiting effect on the level of the renal production of prostaglandins (a vasodilator), they can induce a rather severe and sometimes irreversible impaired renal function. By the same mechanism, they can also create a hydrosodée retention important, being able to cause or débalancer an arterial hypertension. They will create also edema. All these effects will be amplified by a preexistent state of dehydration.

Finally, the AINS can, in a idiosyncratic way (i.e without regard with the amount or the chronology of administration), to cause an interstitial nephritis (renal infiltration by inflammatory cells) of variable severity.

External bonds

MedlinePlus Information one naproxen
FDA Statement one Naproxen, released December 20, 2004
Alzheimer' S Disease Anti-Inflammatory Prevention Trial

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