Medicine orthomoléculaire

The medicine orthomoléculaire proposes to look after the people by the optimal contribution of naturally known substances of the organization, in opposition to the approach known as allopathic which is directed rather towards the therapeutic effects of molecules created by the man.

The term “orthomoléculaire”, created in 1968 by the professor Linus Pauling (Nobel Prize of chemistry in 1954 and Nobel Prize of peace in 1962), means “correct molecule” with the direction “which is not foreign with the human body, which is biologically correct”, the others Molécule S (active ingredients of the majority of the Médicament S) being seen like biologically incorrect -- their chemical resemblance with legitimate substances enables them to interact with the molecules of the body, but as they are not identical to the molecules which they imitate, they cause of the dysfunctions (side effects) and their required effects raise more chemical cheating than of the suppression of the causes of the Maladie.

Medicine orthomoléculaire proposes to treat by the modification of the concentrations of the naturally known substances of the Human body, by opposition of the chimiotherapic practices of conventional medicine using of the substances created of novo and unknown factors of the human body, and thus potentially toxic (and advantageous until the expiry of their patents). The genetic differences can make so that certain substances (Enzyme S, Protéines) are produced in inadequate quantities by the body, creating by there chemical imbalances, which could possibly be mitigated by the additional contribution of one of the terms of imbalance.

The development of the Hunting, the Agriculture and the modern Civilization took place in less 30 000 years and completely our lifestyle and of nutrition changed. This duration is very short on the level of the evolution. Thus we are probably genetically maladaptés with our modern mode.

The study of the food mode of the Primate S genetically closest to the mankind (Gorille S and Singe S) led to note that those have a nutrition extremely different from ours and that they introduce, in particular, some micronutrients in quantities much larger (with equal calories) that we do not do it.

The vitamin C like illustration of the approach orthomoléculaire

The vitamin a.c. popularized by the double Nobel Prize Linus Pauling.

For example, the wild Gorille of mountain (weighing from 120 to 160 kg) introduces daily between 2 000 and 4 000 Mg of ascorbates (Vitamin C) and sometimes much more. The average Western man not taking supplements consumes a few tens of milligrams of them, and the recommended daily contributions of vitamin C are of 60mg.

To note that the majority of the mammals synthesize their own vitamin C in variable quantities according to the stresses undergone which would be equivalent, by taking account of the body mass, with 10 000-20 000 Mg per day for a human adult of average stoutness.

All the anthropomorphic animals, including the human ones, suffer from a genetic error preventing them from synthesizing the enzyme L-gulonolactone oxydase. This enzyme intervenes in the last stage of a feedback path making it possible to convert the Glucose into Ascorbic acid. This genetic mutation would have intervened approximately 25 million years ago.

Among the others Mammalian S which cannot synthesize the vitamin C is the guinea-pigs and an Indian species of Chauve-souris fructivore ( Pteropus middle finger ).

Medicine orthomoléculaire proposes to correct this deficit by the contribution of quantities comparable with those synthesized by the others Mammifères, namely several grams per day (quantity standardized according to the body mass). The extraction of ascorbic acid in such quantities starting from natural sources would be extremely expensive. The adoption of a mode of Nutrition similar to that of these primates does not seem compatible with the civilation. It is thus advisable to use ascorbic acid of Synthèse.

To note that certain people think that the vitamin C of synthesis is harmful or ineffective. One finds in the trade of the shelves of vitamin C obtained starting from Cerises acerola. Those are much more expensive, with the kilo, than the ascorbic acid in the form of crystalline powder which one can obtain from other sources. As an indication, it is possible for the private individuals to get pharmaceutical L-ascorbic acid for a variable price between 15 and 60 euros the kilo.

The ascorbic acid of synthesis is identical in composition and Chiralité to the natural ascorbic acid. Its production always requires a stage of fermentation using Microorganisme S. The clinical trials did not highlight any difference in effectiveness between the vitamin C of synthesis and the natural vitamin C. Shelves of vitamin C extracted starting from sources natural can however contain other beneficial substances, in particular flavonoïdes. Nevertheless, the most important factor in the therapeutic effectiveness of the vitamin C is the amount. Provided that it is taken with the same amounts, the vitamin C of extraction is thus as effective as the vitamin C of synthesis, but ten times more expensive: about 500 euros the kilo. Thus a year in vitamin C “Acerola” with 6 grams per day will cost more than thousand euros. In vitamin C of synthesis that totals 100 euros per annum. Moreover, the Flavonoïde S can be taken separately, in the form of fruits for example.

Clinical benefit and threshold of effectiveness

The benefit of variable and sufficient amounts of ascorbic acid in many medical situations can be spectacular and very rapid, particularly during infections (the Phagocyte S use ascorbic acid taken in blood as antioxydant to protect itself whereas they attack the intruders using oxidants like the Hydrogen peroxide) or at the time of convalescence following burns (the ascorbic acid is also necessary to the production of Collagène).

The scientific rigor requires however clinical trials as a double-blind man. The amount necessary to the improvement can be very variable. If a few tens of milligrams prevent the acute Scorbut, the cure of one viral infection can ask for several tens of grams per day. Unfortunately certain articles studying the benefit of the vitamin C and conclusive to weak or statistically unimportant benefit use amounts which one could describe as nutritional, i.e. lower than one gram per day. For the man, the vitamin C not being synthesized, one can think that the body allocates it in priority with the most important tasks. Let us suppose schematically that the maintenance of the integrity of the blood-vessels passes before the control of an infection. If 5 000 Mg are necessary to their maintenance, the administration of 5,000mg of vitamin C could have only one negligible effect on an infection, while the administration of 20 000 Mg could have an effect definitely more beneficial.

Is this the panacea?

The reader skeptic can wonder how the existence of such a panacea could be also ignored. The dynamics of the vitamin C in the body is not completely elucidated. Regarded a long time as a Micronutriment, its consumption with amounts higher several orders of magnitude than the other vitamins and the minimal quantity preventing the acute scurvy can appear absurd. The inconclusive clinical trials carried out with insufficient amounts undoubtedly sowed confusion. One cannot deny either that, not being patented and not very advantageous, it could be voluntarily neglected.

The vitamin C could be a Panacée same manner that the Insuline of synthesis is a panacea for the diabetics. As one mentioned above, the human ones (and other primates) suffer from a genetic disease which we could call anascorbemy who make that they do not synthesize this substance. As this one is absorbable by oral way (or intravenous in the form of Ascorbate of sodium exclusively) it follows that the regular and massive ingestion of this substance makes it possible to mitigate this genetic defect.

Would the vitamin C be toxic?

Since its synthesis in the Years 1930, the vitamin C is used with all amounts throughout the world. The only side effects associated with its use and which are benches are the benign Diarrhée and a diuretic action. Those occur when it is consumed too quickly and in too great quantity. The organization which cannot store it, it eliminates excess thus.

The clinical studies show:

that the Consommation of vitamin C does not increase (ref. 5,6,7) and even reduced (ref. 8) the incidence of renal calculi.
that the vitamin C does not have a mutagen effect (study on amounts going until 5000mg per day)

(ref. 9,10)

In vitro studies show that the vitamin C, even in the presence of metals of transition does not have mutagen effect and that on the contrary it protects the cells from the action mutagen of the Hydrogen peroxide (ref. 7).

In conclusion, the vitamin C is absolutely not toxic.

Other vitamins and minerals having a therapeutic effect

If a food balanced with the conventional direction of the term is a requirement but nonsufficient for a good health, the contribution of certain minerals, vitamins, oils or other nutrients in quantities quite higher than those which one usually introduces is effective to deal with many affections.

Combination of Magnesium (several hundreds of Mg per day) and of Vitamin B6 (from one hundred to two thousand Mg per day) is often prescribed to treat the Syndrome of the carpel tunnel, the Premenstrual syndrome. Its effectiveness as a double blind man against placebo was shown in the treatment of the infantile Autisme.

The Niacine (Vitamin PP or Vitamin B3) is used in conventional medicine for its hypocholestérolémiant effect. The Nicotinamide is another shape of this vitamin which can relieve the ostéoarthrite, the schizophrenic depression and disorders or referring itself to it. The vasodilator effect of the niacine lets think that it could relieve the migraines.

The Zinc is effective against the infections.

Warning

If the vitamin C is atoxic with all amounts, it is not thus of all the vitamins, nor of minerals. There is always a Risque of interaction with other medicamentous treatments. A certain number of doctors seem to be unaware of or scorn the therapeutic value of these micronutriments. If the latter are available without regulation, it is advisable to ask council its doctor or his pharmacist to avoid the Toxicité certain vitamins.

JAMA 2007 méta-analyzes

A Danish and Serb team with published in February 2007 méta-analyzes of all the randomized tests using of antioxydants in primary prevention and secondaire.
All the studies randomized in the adults comparing the Beta-carotene, the Vitamine has, the Vitamine C, the Vitamine E or the Sélénium, is in a way isolated or combined with a placebo or l´absence d´intervention were included in this analysis what represents 68 studies randomized bearing on 232.606 participants.

The results of this méta-analyzes does not show d´effet significant antioxydant supplements on mortality (RR = 1.02, IC 95% 0.98-1.06). The analyzes in multivariate méta-regression showed that the studies having weak skews and selenium (RR = 0.998, IC 95% 0.997-0.9995) were significantly associated with mortality. In 47 of the studies with weak bearing skew on 180.938 participants, the supplements by antioxydants increased to a significant degree mortality (RR = 1.05, IC 95% 1.02-1.08). After exclusion of the tests relating to selenium, Beta-carotene (RR = 1.07, IC 1.02-1.11), the vitamin has (RR = 1.16, IC 1.10-1.24) and the vitamin E (RR = 1.04, IC 1.01-1.07) in an isolated or combined way increased to a significant degree mortality.

The authors thus conclude that:

the Vitamin C and the Sélénium n´avaient not d´effet significant on mortality.
the Beta-carotene, the Vitamine has and the Vitamine E could increase mortality.

See Too

Antioxydant
not-conventional Medicine
essential Nutrient
Vitamin

References

Random links: