The métronidazole is a Antibiotique and Antiparasitaire pertaining to the Nitroimidazole S. It inhibits the synthesis of the nucleic acid and is used for the treatment of the Infection S related to Bactérie S Anaérobie S like with Protozoaire S.

It is effective against, inter alia: Giardia lamblia , Entameba histolytica , Trichomonas vaginalis , difficult Clostridium , Helicobacter pylori .

The métronidazole is used in the treatment of pseudomenbraneuses colites, this is why one can find it associated with other antibiotics such as the related macrolides being able to cause this type of disease.

The " métronidazole" (antibiotic) is also prescribed for the treatment of the Rosacées (standard Erythrogel or Rozagel) and of the Télangiéctasies.

Side effects

It was shown in vitro that the métronidazole reacted to ordinary temperature with the glutathion. Its structure is to be compared with that of the imurel (which is also a nitroimidazole), and it is logical to think that it can be a source of immunodéficience.

The métronidazole is very bitter and has a persistent metal after-taste which often involves inappétence. It can cause headaches. The use at long life and strong amount can involve Névropathie S peripherals.

The métronidazole has a Effet antabuse: association with the alcohol in some form that it is (including Sirop cough mixture) is to be proscribed because it can cause severe nausea S and cramps.

The catch of métronidazole gives a color sunk to the urine.

• Pregnancy: Teratogenic and mutagen effects cannot be excluded with certainty. In Belgium, the handling and the realization of preparations containing métronidazole are prohibited during the pregnancy.

The métronidazole potentiates the action of the anti-vitamins K and thus increases the hemorrhagic risk.

Pharmacology

The métronidazole can be managed in oral, intravenous form or topic. In oral form, it is absorbed and passes in circulation where it has a half-life from 6 to 8 a.m. It penetrates in the céphalo-rachidian liquid.

As the métronidazole crosses the placental barrier, it should be used with precaution during the pregnancy. In Canada, it is particularly contra-indicated during the 1st quarter, unless no other treatment is available.

Proprietary medical products containing métronidazole

Oral forms

Parenteral forms

Forms topics

Dermic forms

Vaginal forms

Various: dental use

References

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