In 1875, it obtains a title of doctor of medicine with Montpellier with a thesis entitled physiological Étude on the action of the poisons . He is professor of comparative Embryologie to the Collège de France, member of the Académie of medicine, the Académie of agriculture and the Academy of Science. Its lessons of the Collège de France appear under various titles like the Leçons on the generation of vertebrate the (lessons of the six-month period of winter 1877 - 1878) or Leçons on the cell, morphology and reproduction (lessons of the six-month period of winter 1893 - 1894). It passes its aggregation in 1883 with a report entitled the useful lichens .
Henneguy studies the Phylloxera and makes appear reports/ratios on the destruction of egg of winter of will phylloxera in 1885, 1887 and 1888. He also studies, on behalf of the advisory committee of maritime fishings the sale and the consumption of the mould S in any season. In 1891, it studies the natural history of the Anthonome of the apple tree and the means for its destruction.
Henneguy directs the publication of the Archives of microscopic anatomy starting from 1894. He is also the author of:
- the vitelline Body of balbiani in egg of vertebrate the ;
- Lessons on the cell ;
- the insects ;
- On parthenogenesis experimental in the Amphibians.
- Translation of the work of Arthur Bolles Lee (1849-1927), Treated technical methods of the microscopic anatomy: histology, embryology and zoology (O. Doin, Paris, 1887, republished in 1896 and 1902).
- Research on the development of osseous fish (Felix Alcan, Paris, 1889).
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