Loss of hétérozygotie
The loss of hétérozygotie (or loss off heterozygosity: LOH in English) of a cell represents the loss of genetic material coming from one of the two parents. The loss of hétérozygotie can occur by different ways, like a Délétion, a genic Conversion, a mitotic Recombinaison or a chromosomal Perte.
History
The study of the Caryotype S of the solid tumors made it possible to show the existence of chromosomal anomalies recurring. The loss of a chromosomal Segment by rehandling, that it is by Délétion or by a mechanism of Translocation unbalanced is often associated with the loss of one of the two parental alleles. The search for genes transferred on the preserved allele showed that share this mechanism the genes suppressors of tumors were inactivated, which has to confirm the bond with the inactivation of genes suppressors of tumor according to the Théorie with two events of Knudson.
Technique of detection
Various techniques make it possible to highlight a loss of hétérozygotie of which the Cytogénétique or the Allélotypage.
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