Lamina
The nuclear envelope is bordered (with dimensions nucleoplasme) by a dense fibrillary grid called nuclear lamina . It is about a fibrous, homologous proteinic network with the intermediate Filaments which doubles the internal membrane of the envelope nuclear forming a layer from 10 to 20 Nm thickness and stopped by nuclear pores. This network is composed of Polypeptide S called roll (of 3 different types: Roll has, Lamine B and Rolls C. Rolls has and Rolls C are quasi-identical) With the difference of the intermediate Filaments, the nuclear lamina has a longer central field and a nuclear signal of localization. It forms a network with square and dynamic mesh (it is disassembled at the beginning of mitosis to reform itself at the end of the mitosis, thanks to a mechanism of phosphorylation and dephosphorylation).
It is thought that the nuclear lamina is used for fixing of the Chromatine S with the periphery of the core and represents a structural support for the nuclear envelope. It is called also nucléosquelette.
External bonds
- Inserm U491 : Roll and Laminopathies
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