Lévofloxacine
Lévofloxacine is the international non-proprietary name of an antibiotic of the family of the fluoroquinolones, marketed in Europe by Sanofi-Aventis with the name of mark Tavanic . The lévofloxacine is an enantiomer of the isomer form L of the Ofloxacine. Its action is to prevent the bacterial replication by blocking the enzymes DNA gyrase necessary to the opening of the double bacterial helix of DNA.
The lévofloxacine is bactericidal and effective on the bacteria Gram-positive S and Gram-negative S. Its broad spectrum of action makes it particularly effective on the germs responsible for infections pulmonary and sphere ORL. This treatment is largely used on the hospital germs responsablent of infections nosocomiales.
Usually sensitive bacteria Gram-positive S:
- Enterococcus faecalis
- Staphylococcus aureus (Méthicilline - sensitive)
- Staphylococcus epidermidis (Méthicilline - sensitive)
- Staphylococcus saprophyticus
- Streptococcus pneumoniae (even of sensitivity decreased to penicillin)
- Streptococcus pyogenes
Usually sensitive bacteria Gram-negative S:
- Enterobacter cloacae
- Klebsiella pneumoniae
- Pseudomonas aeruginosa
- Escherichia coli
- Legionella pneumophila
- Serratia marcescens
- Haemophilus influenzae
- Moraxella catarrhalis
- Haemophilus parainfluenzae
- Proteus mirabilis
- Campylobacter
Others:
- Chlamydia pneumoniae
- Mycoplasma pneumoniae
- Peptostreptococcus sp.
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