Inhibiter of recaptures serotonin-noradrenalin

The inhibiting of recaptures serotonin-noradrenalin or IRSNA as they are called, inhibit in a selective way recaptures it Noradrénaline and Sérotonine. They will thus not have, unlike the tricyclic antidepressants, of action on the Dopamine. This inhibition involves an increase in the concentration Synaptique of these neurotransmitters. Within a few week, one will observe a " down regulation" (reduction) of the receivers postsynaptic 5HT2A with postsynaptic serotonin and β with noradrenalin, receivers being of too significant number at the depressive one.

molecules and trade names

Venlafaxine Effexor®
Milnacipran Ixel®
Désipramine which was withdrawn from the market in France
Néfazodone which is not marketed in France

therapeutic indications

treatment of the major depressive episodes in the adult
the venlafaxine could be used in the prevention of the depressive repetitions at the unipolar patient

undesirable effects

This family of antidepressants will be better tolerated than that of the tricyclic , but will be less effective.

anticholinergic effects: oral dryness and urinary retention.

peripheral effects noradrenergic: increase in the blood pressure

peripheral effects serotoninergic: nauseas and vomiting.

effect anti H1 (Histamine) central: especially with the venlafaxine, important sedative effect.

one also observes with the milnacipran a lifting of suicidal inhibition.

counter-indications

These molecules against are indicated in case:

of Adenoma of the prostate
of arterial Hypertension
of angina pectoris

It will be necessary to reduce the Posologie half in the event of impaired renal function or hepatic.

medicamentous interactions

absolute Counter-indication with nonspecific IMAO (Iproniazid) and with the triptans.
associations disadvised with the selective IMAO has, adrenalin and noradrenalin…

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