Hormone thyréotrope

The hormone thyréotrope ( TRH , according to its English name Thyrotropin-releasing hormone ) or Thyréolibérine is a tripeptidic Hormone produced by the Hypothalamus which stimulate the dropping of thyréotropine (TSH) and of the Prolactine by the former pituitary gland.

The pituitary gland has an action on the thyroid one via the TSH. Itself is under the control of a factor hypothalamic: the TRH. TSH and TRH are responsible for the increase in the iodine collecting, of the synthesis of the thyroid hormones and their put in circulation in blood .

It is with Roger Guillemin and Andrew V. Schally (in 1969) that one owes the discovery of the peptide sequence of the human TRH as well as the first synthesis of the hormone.

One can also detect the presence of TRH in other parts of the brain, like in the digestive Système and the small islands of the Pancréas. Medical preparations of TRH are used in the diagnostic tests of the disorders of the Thyroïde like in the event of Acromégalie.

Structure

(pyro) Glu-His-Pro-NH₂

Molecular weight

359,5 Unit of atomic mass

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