Gq (protein)
The proteins Gq are one of the principal families of the Protéines G associated with a receiver. It is amongst other things about the Récepteur muscarinic with the Acétylcholine, located at the level of the cardiac muscles. These receivers consist of 3 respectively called sub-units α, β, γ. But only first is able to fix a molecule of GDP (Guanosine Diphosphate) or GTP (Guanosine Triphosphate).
Operation of the receiver
The reception of the hormone causes the setting in motion of the Gq protein in form GTP, which will activate the phospholipase C β (see). This protein catalyzes reaction PIP2:PIP2 (Phosphatidylinositol biphosphate) --> IP3 (tri Inositol phosphates) + DAG (DiAcylGlycérol).
See
IP3 joins a channel endoplasmic Réticulum what causes the release of Ca++ (ion calcium). Active DAG PKC (protein Serine Thréonine dependant kinase Ca), sufficiently usually activated by the normal Ca rate.
PKC generates then a cascade of Phosphorylation, not passing by necessary by proteins SHORT-NAP CLOTH () and RAF, and which ends up activating a MAP kinase () leading to the activation of factors transcriptionnels (like AP1)
Related article
- Kinase and Protein kinase
- Peptidase
- Oncogène
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