Folliculo-stimulative hormone

The folliculo-stimulative hormone , hormone peptide (glycoprotéine) drawing its name from English Follicle Stimulating Hormone (FSH), is composed of two chains (alpha and béta) and has a structure similar to that of LH (Luteinizing Hormone), TSH and HCG. The FSH is produced by the Ante-pituitary gland, its secretion is stimulated by the GnRH (Gonado Tropin Releasing Hormone) produced by the Hypothalamus. The secretion of GnRH is pulsatile and the frequency of the cycles determines the report/ratio of secretions of FSH and LH.

This hormone has as a target the Gonade S on which it has the following effects:

at the woman:

# stimulates the cells of the Granulosa which secrete Estradiol and Inhibine B and express receivers for the LH;

# stimulates the cells of the internal Thèque which produce the Enzyme aromatase able to convert the Androgène S into estrogen S;

# involves the growth of the follicules

# allows the Ovulation by weakening the wall of the ovary.

at the man:

# stimulates the cells of Sertoli which secrete Inhibine B and are essential to the Spermatogénèse.

Before puberty, the rate of FSH in blood is weak. At the woman, it becomes cyclic during the adult life - except during the pregnancies - and high after the menopause.

The methods of proportioning are done by radioimmunology. The plasmatic half-life is from 1 to 3 a.m.

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