Fibroblast

Description

It is a spindle-shaped with Cytoplasme sometimes spangled, long from 20 to 30 μm and broad cell from 5 to 10 μm (its often short prolongations are sometimes ramified). The core is oval with Chromatine condensed (in peripheral mound) and a Appareil of Golgi which is peripheral for him.

This cell has a cytoplasm rich in endoplasmic Réticulum rough (REG.), Ribosome S free and Mitochondrie S. Moreover it contains a network of microphone-filament of Actine and vimentine.
Elle secretes protéoglycanes, glycoprotéines and glycosaminoglycanes. One observes on the surface of the fibroblasts of the receivers with the LDL and the HDL.

Role

The fibroblast has several roles in the organization:

protective Role of the athérome thanks to the metabolisation of the Cholesterol.
Renewal of the Collagenous and proteins of fibers thanks to their manufacture and also their destruction ensured by Métalloprotéase S (collagénases and protease S).
anti-infectious and antiviral Defense by the chimiotactic secretion of factors S and Interféron β.

Derived from the fibroblast

the Fibrocyte is a fibroblast with a less activity what results in a denser core and less developed organoids.

It can sometimes find a fibroblastic activity at the time of phemonenes of cicatrization by having however a less activity of division.

the myofibroblaste is identical to a fibroblast with however microphone-filaments of actine associated with microphone-filaments of myosine, the microphone-filaments of vimentine are them associated with desmine microphone-filaments.

Origin of the fibroblasts

At the embryo they derive from the mésenchymateuses original cells.
In the adult their origin is local. They can derive from the mésenchymateuses original cells (morphologiquement comparable with small fibroblasts) laid out along the capillaries.

See too

growth factor of the fibroblasts

Random links: