Excipient

In the Cosmetic S

The excipient is the vector or conveys active ingredient. It makes it possible the active ingredient to arrive there or it is supposed to act. The excipient thus does not interfere with the active ingredient. The excipients have sometimes certain cosmetologic properties and can then play the part of active substance. The excipient is always much more important in volume than the active ingredients. Moreover, it is him which defines the Galénique product i.e. its consistency (cream, freezing…) and its aspect. The most used excipients are the Huile S, the Eau and the alcohol. For example, the soft Almond, the lawyer or butter it Karité are excipients of vegetable origin. The Silicone S are an example of synthetic excipient of origin.

In the Drug S

The drug consists of one (or several) principle (S) active (S) and of substances of packing (excipients) which will confer on final drug qualities of stability, forms, dissolution, targeting, taste, color, esthetics, etc These substances identified in the formulas in their ponderal order are extremely varied.

The excipients take part fully in the mode of action of the drug. Without excipient, not of drug. The art of medicamentous working, it is the galénique one. The excipients are thus substances closely associated with the active ingredients with the drugs which:

should have a perfect harmlessness, in any case in the range of the concentrations used into galenic. Those should not lead to any toxicity. In fact a certain number of excipients are famous for notorious purpose due often to allergic phenomena or individual intolerances (enzymatic insufficiency for example);
stabilizes an active ingredient (the Liant S, the Diluant S, conservatives);
solubilizes it (hydrophobic e.g. substance in an oil or an emulsion);
allows a correct and targeted dissolution (Surbedding S), for example in glass, the stomach or front in the digestive tract);
gives him a form (gélule, suppository, freezing, drops, liquidate, etc) in connection with the mode of administration ( per bone , injectable (SC, IV, IM), transcutané, etc);
can give him a sapidity necessary (e.g. the sweetening substance S), when the taste of the active ingredient is “extreme”, or to facilitate a pediatric use;
allows the targeting;
modifies the biodisponibility, the half-life;
etc

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