Ethylglucuronide

The ethylglucuronide , known as " EtG " in shortened, is a natural form of the ethanol.

Definitions

the ethylglucuronide (C8H14O7) is a Métabolite of phase II of ethanol, mainly formed in the Foie. For a quantity of Ethanol introduced, one eliminates approximately 0,02 to 0,06% in the form of EtG, molecule not-bird, water-soluble and stable with the conservation.

French Name: ETHYLGLUCURONIDE
English Names: Ethyl glucuronide
N° of CASE: 17685-04-0
molecular Formula: Molecular C8H14O7
Mass: 222 g/mol.
Synonymous: ETHYL a-D-GLUCOPYRANOSIDURONATE

Derived from the glucuronic acid, EtG is one of the endogenous compounds, which, with sulfate and the glycine, use the reactions of conjugation (reaction of the synthetic type) of phase II of detoxification of ethanol. In 2004, Erlich and Schroder define the glucuronides, of which EtG, like glycosides of the glucuronic acid formed by the reaction between the glucuronic acid and the diphosphate uridine with certain endogenous and exogenic substances.

Properties

The formation of the glucuronides is important for the detoxification of drugs, the excretion steroid and the metabolism of the bilirubine to obtain a more water-soluble compound which can be eliminated in the urine and the bile.

New marker of abusive alcohol consumption

Since the end of the 20th century, several researchers studied themselves of the éthylglucuronide like one of the tracks of development of new markers of abusive alcohol consumption. They consider that EtG is serious and promising candidate marker of alcohol consumption (Skopp 2000), but presents a short window of detection in the Sang or the Urine S.

Analyzes and detection

In the hair, EtG can be detected for one period of time prolonged after alcohol the complete elimination of the organization, because the keratinized fabrics are known to maintain the substances exogenic and to provide a broader retrospective window of detection than of the body fluids.

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