Dysplasy (pathological anatomy)
See also: Dysplasie (homonymy)
In pathological anatomy one speaks about dysplasy in front of an acquired deterioration of architecture and function of a cellular fabric with fast renewal (osseous Moelle, epithelium of coating,…). The dysplasy has a total tendency to evolve to a Cancer, which makes of it the sometimes abusive synonym of précancéreux state.
Microscopic characteristics
The morphological cellular anomalies which characterize it generally relate to the core and the Cytoplasme, with frequently an increase in the nucléo-cytoplasmic ratio (increase in the size of the core compared to the size of the cytoplasm). The cells of a fabric dysplasic are often little differentiated. On a tissue scale one observes a modification of the architecture which can go from the tiny increase in the cellular Division to the exuberant proliferation. According to the extent of the anomalies and the tendency to proliferation one distinguishes, by order ascending of malignant risk of degeneration, the dysplasies of low rank and the dysplasies of high rank. The dysplasy is always strictly localized with fabric where it is born and can thus, if it is detected in time, profit from an effective assumption of responsibility.
Dysplasy in human pathology
The dysplasy can be marked only by the microscopic examination of a tissue taking away. It occurs secondarily with an aggression repeated and prolonged on a fabric, either directly, or after passage by a stage of Métaplasie. An example running of dysplasy in human pathology is the cervical Dysplasie, which is the target of tracking by smear on the Cervix.The stage of dysplasy precedes a great number of cancers and is thus the privileged target of the examinations of Dépistage carried out on a purely collective or individual basis.
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