The dynéines are proteinic complexes from 9 to 12 structural sub-units, from approximately 2 MDa, always associated with Microtubule S. According to their localization they have different activities.

Activities of the dynéines

One distinguishes:

• the dynéines axonémales

They are fixed at the one of the Tubule S of the doublets present in periphery of a Axonème. By an activity asic ATP, they make slip the tubules between them, causing their curve. All the tubules slipping simultaneously, the lashes and the Flagelle S are thus put moving.

• the cytoplasmic dynéines

They are fixed on the Microtubule S of the Cytoplasme. By a ATPasique activity, they allow displacements of Vésicule S which are associated to them, towards the center of the cell, i.e. towards the negative end of the microtubules. This type of transport is particularly developed in the Axone S and the dendrite S of the nervous cells. They are also implied in the migration of the intermediaries prégolgiens towards the Appareil of Golgi.

Pathology

An absence (Genetic deficit ) of dynéine is responsible due syndrome for the motionless lash of to the absence of beats ciliaires responsible for bronchitides chronicle and of sterility at the man owing to lack of mobility of the Spermatozoïde S. It east can be also responsible for the Syndrome of Kartagener characterized by a syndrome of the motionless lash associated with a situs inversus.

See too

• Kinésine

External bonds

• How Cilia and Whipped Work (axonemal dynein)

• Microtubule Based Movement (cytoplasmic dynein)

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