Docétaxel
The docétaxel is an anti-cancer active ingredient. It is a Alcaloïde synthesized in France (1989), pertaining to the family of the Taxane S (or Taxoïde S), by hemisynthesis starting from the needles of the European yew ( Taxus baccata ).
The docétaxel is an analog of the Paclitaxel, structure and activity neighbors, but it remotely especially by its toxicity and its antitumor effectiveness. Like him, it supports the maintenance of the Microtubule S by inhibiting to them Dépolymérisation by stable connection with the Tubuline and involves a blocking of the Mitose. It is used with the amount of 100 mg/m ² every 3 weeks by venous way, in one hour perfusion. It is toxic for the osseous Moelle (lowers Leucocytes and Plaquettes) and involves reactions of Hypersensibilité, a retention of water d' with edema S and épanchement S and of the central nervous system disorders. It is effective in many Tumeur S but mainly in the metastatic breast cancers, resistant to the Anthracyclines or in relapse, in the Lung cancer and of the prostate.
Commercial forms
Belgium and France: reserved with the hospital use.
Source
- FNCLC
External bonds
- Taxotere
- Taxotere
- Docetaxel
| Random links: | Giuseppe Garibaldi | Progressionism | US Chaouia | Oscars of the cinema 1989 | Ju 388 Störtebeker | Fleuve_de_Willamette_de_fourchette_de_côte |