Disease of Kaposi

The sarcome of Kaposi is related to the infection by the Herpèsvirus human HHV8. The traditional form which causes cutaneous Tumeur S of the ends in the elderly was described at the end of the 19th century in the Mediterranean circumference. This virus which exists in endemic form in Africa develops particularly at the individuals Co-infected by HIV and HHV8. The epidemic of AIDS thus caused an explosion of the number of cases of sarcomes of Kaposi. In Europe and in the United States, the disease touches especially the homosexual male contrary to Africa where the transmission seems to be done in a preferential way of the mother to the child and from one child to another. There exists in addition of many asymptomatic carriers.

Clinical signs

  • the cutaneous attack begin with a Macule which evolves to a Papule, a nodule then a plate ulcérovégétante. This lesion is well limited, érythémateuse then purplished, and can simulate a Hématome first of all. Lesions are of the variable, located or generalized size. The evolution is it also very variable, very slow or progressing quickly.

  • the attack Muqueuse is observed in more than 50% of the ocular case, is buccopharyngée ( palatine, gingival, labial, jugale, lingual, amygdalienne ), ano-genital or .

  • the visceral attack makes all the gravity of the disease of Kaposi, in particular the pulmonary attack . The clinical signs are not very specific: Cough, Dyspnea, Fever prolonged. The radiological signs are late, in the form of fuzzy nodules, badly limited, symmetrical, with possibly épanchement pleural. The thoracic scanner, the Bronchoalveolar Washing (LBA) and the bronchial fibroscopy are a help with the diagnosis.

Treatment

The treatment of the disease of Kaposi calls upon general and/or local treatments.

In the framework of the infection with HIV, the general treatment is indicated in the event of extensive cutanéomuqueuses lesions and/or of visceral attacks. It calls upon a monochimiothérapie bléomycine if the cutaneous lesions are wide and not very evolutionary visceral lesions. If the cutaneous lesions are œdématiées and the serious visceral lesions, it rests on a poly Chimiothérapie associating Adriamycine, Bléomycine, Vincristine, and/or Vincristine, Vinblastine and Anthracycline S.

The local treatment is indicated in the case of reached cutanéomuqueuses stable and limited.

See too

External bonds

  • http://www.thachers.org/internal_medicine.htm
  • http://hivinsite.ucsf.edu/InSite?page=kb-authors&doc=kb-06-02-01
  • " What Butt the Relationship Between Alkyl Nitrites and KS? , Christine Weber, B.Sc
  • Nitrites and KS/HIV/AIDS, history, sociology
  • old teaching Moulding, wax of it (Collection of the Saint-Louis hospital)

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