Diclofénac

The Diclofénac is a derivative arylacetic, product which enters the class of AINS (Anti inflammatory not stéroïdien) and which is widely diffused in the world Pharmacopée under various names.

Presentation

  • Compressed
  • injectable Form (Muscular Intra)
  • Suppository S
  • cutaneous Topic

Indications

Anti-inflammatory drugs, antirhumatismaux not stéroïdiens (code ATC: M01AB05). The diclofénac is an anti-inflammatory drug not stéroïdien derived from the Phenylacetic acid of the group of the acids arylcarboxylic. It has the following properties:
  • antalgic activity,
  • activity Antipyrétique,
  • anti-inflammatory drug activity,
  • plate inhibition of short duration of the functions S.
The whole of these properties is related to an inhibition of the synthesis of the Prostaglandine S

Against Indications

  • Beyond 5 months of pregnancy completed
  • Previous of allergy or Asthma started by the catch of diclofénac or substances of close activity, such as other AINS, aspirine.
  • Over-sensitiveness with the one of the excipients.
  • Ulcer gastroduodénal in evolution.
  • severe hépatocellulaire Insufficiency.
  • severe Impaired renal function.
  • not controlled severe Cardiac failure.
  • Child of less than 16 kg, because of the unsuited proportioning of this drug.
  • Previous recent of Rectite S or rectorragies (counter-indication related to the route of administration): suppositories with 25 Mg and 100 Mg.
  • Turbid of the Hémostase or anticoagulant treatment in progress; counter-indication related to the intramuscular way (injectable solution with 75 mg/3 ml).

Metabolism

The diclofénac is metabolized quickly and practically completely, primarily on the level of the Foie. The excretion is at the same time urinary and fecal. The plasmatic half-life of elimination of the unchanged diclofénac is around 1 to 2 a.m. The total plasmatic clearance is approximately 263 ml/minute.

Veterinary medicine

The diclofénac is used for the cattle in India. See medical Vautour#Problème in India due to the reduction in the number of vultures

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