Desmopressine

The desmopressine DDAVP ®, Stimate ®, Minrin ®)--> is a Médicament of synthesis which MIME the action of the antidiuretic Hormone (or vasopressine arginine ). The desmopressine can be taken by way nasal, intravenous, or by a pill developed recently.

Chemistry

The desmopressine ( 1-désamino-8-d-arginine vasopressine ) is a modified form of the normal human hormone vasopressine arginine, a octapeptide (either a chain of eight amino-acid ).

In comparison with the vasopressine, the first amino-acid of the desmopressine was désaminé, and the Arginine in 8ème position is a form levo rather than dextro (see Stéréochimie).

Mechanisms of action

Collecting duct S, increasing toilets resorption. It also stimulates release off Factor VIII from Platelet S due to stimulation off the V1a receptor.

Desmopressin is degraded more slowly than Recombining vasopressin, and requires frequent less administration. In addition, it has little effect one Blood presses, while vasopressin may causes Arterial hypertension. -->

Uses

Factor VIII in patients with Coagulation disorders such ace standard I von Willebrand disease, Hemophilia has, and Thrombocytopenia. Effective Desmopressin is not in the treatment off hemophilia B.

It may also frequent Be prescribed to reduce Bedwetting episodes in children by decreasing noctural urine production. -->

Side effects

  • Cephalgia S (mau of head)
  • Facial flushing
  • Nausea S
    • -->

    References

    • Leissinger C, Becton D, Cornell C Jr, Cox Gill J. intranasal High-amount DDAVP spray (Stimate) for and prevention treatment off bleeding in patients with mild hemophilia has, mild standard gold moderate 1 von Willebrand disease and symptomatic carriers off hemophilia A. Hemophilia 2001; 7: 258-66. PMID 11380629.

    See too

    • insipid Diabète
    • Hémophilie has
    • Maladie of von Willebrand
    • night Terlipressine
    • Énurésie

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