Desflurane

The desflurane is a volatile Anesthetic agent of the family of the ethers halogenous S used for the maintenance of the general anesthesias. Its good clinical tolerance and its pharmacological behavior allowing a fast alarm clock gradually made it prefer, with the Sévoflurane, with the older molecules (Halothane, Enflurane and Isoflurane) in the Western countries.

History

The desflurane is one of most recent anesthetic halogenous: it was introduced into the years 1980.

Properties

The mode of action of the desflurane remains partially unknown. Managed with the mask thanks to an anesthetic spray, it is generally associated with the Protoxyde of nitrogen and the Oxygène. Its bitter, irritating for the mucous membrane of the air routes, prohibited odor its administration for the induction of the anesthesia. Its CAMWOOD is of 6% vol. Its low solubility plasmatic made of him the anesthetic agent whose kinetics is fastest, allowing an alarm clock within a time very runs after the stop of its administration. Its relatively high cost is the main obstacle with its generalization: the Isoflurane is sometimes preferred to him for economic reasons.

Undesirable effects

The tolerance of the desflurane as that of the Sévoflurane is overall very good. As all the halogenous gases the desflurane support a arterial Hypotension per-operational and increase the risk of nauseas and post-operative vomiting. Hepatic toxicity or renal of the desflurane at the man is very rare. It is likely, at the predisposed subjects, to start a malignant crisis of Hyperthermie.

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