Dendrimère

A dendrimère is a Molécule whose form takes again that of the branches of a tree. The name comes from the Greek " δενδρον" /dendron, meaning " arbre". In 1979, the first dendrimère was synthesized by D.A. Tomalia and other researchers of Dow Chemical Company, and dendrimères for summer have studied everywhere in the world for their single form.

Synthesis

In the synthesis of the dendrimères, the Monomère S lead to a monodisperse Polymère, a such tree. There are two definite methods of synthesis of the dendrimères: divergent synthesis and convergent synthesis. The first assembles the molecule of the core to the periphery and the second of outside towards the core.

However, because a repeated reaction made up of many stages is necessary to protect the active site, it is difficult to synthesize dendrimères even if the two methods are employed. This is why there are obstacles with the synthesis of great quantities of dendrimères. However, of American research have seems it succeeded in this direction.

Properties and applications

The properties of the dendrimeres are generated by the molecular structures present on its surface. For example, a dendrimère can be water-soluble when its end-group is an absorbent group, like a carboxylic group. It is theoretically possible to conceive a water-soluble dendrimère with the internal hydrophobicity, which would enable him to carry a hydrophobic compound in its interior (in order to transport a hydrophobic therapeutic compound in blood for example).

Another property is that the volume of a dendrimère increases when it has a positive load. If this property can be applied, of the dendrimères can be employed for the chemical transport systems of elements which can directly give the drug to the part aimed inside the body of a patient (tumor for example).

The applications are very diverse like an electroluminescent organic element, like blood Substitut, anti-cancer treatment.

External bonds

Cambridge display technology (anglophone)

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