Cytaphérèse

The cytaphérèse is a technique which makes it possible to take peripheral original cells starting from blood, based on the same principle as the taking away of the plates. It is used to constitute a Greffon within the same therapeutic framework as the bone-marrow graft.

This type of intervention intervenes normally after a medicamentous treatment of a few days containing Growth factor (G-CSF, the such filgrastim or the lenograstim ) making it possible to stimulate the production of these cells and to cause their migration of the osseous Moelle towards the Sang.

The cytaphérèse itself consists in making pass the blood of the donor in a machine, the separator of cells. This machine goes, by Centrifugation, to make it possible to distinctly see the plasma (light and almost transparency) and the red globules (heavy). Between the two, one finds a mixture of Leucocyte S and plate S called “English buffy-coat”. It is this part of the blood which the machine takes because it is there that the original cells are. The other components of blood are returned to the donor.

The purpose of this technique, which lasts between 3 and 5 hours, does not require the hospitalization of the patient and is to avoid the Anesthésie general necessary in the case of the taking away of osseous marrow.

When the number of original cells collected after a meeting is insufficient, one second meeting can be programmed the following day. If, the patient on standby of Clerc's Office already underwent a massive chemotherapy of preparation to the graft and in the rare case where after two meetings the number of cells collected is always insufficient, a taking away of osseous marrow in urgency (thus with general anesthesia) is programmed. In general for an Autograft, the taking away of the original cells is carried out after a first treatment, to hope to collect nonsick cells, but before intensive chemotherapy.

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