Cluster off differentiation

Cluster off differentiation ( CD ) is the English name of molecules which are markers of cellular surfaces, such as specific plays of Anticorps used recognize them to identify the type of cell, the stage of differentiation and the activity of a cell.

Nomenclature

The nomenclature CD was proposed and established by the 1st work group and International Conference on Human Leukocyte Differentiation Antigens (HLDA) (antigens of differentiation of the human leucocytes), in meeting with Paris in 1982. This system sought to classify many monoclonal antibodies (mAbs), produced by various laboratories of the whole world, with respect to various Antigène S of moléculess of surface of Leucocyte S. Depuis at the time, the use is étandu with various other types of cells, and more than 250 clusters CD and under-clusters were identified. Work groups HLDA assign each CD on the basis of reactivity same to a human antigen on at least two mAbs; the provisional indicator " w" (as in " CDw186") is sometimes given to a cluster poorly characterized or being represented only by one mAb.

Uses

The most commonly referred to CD molecules are CD4 and CD8, which different are markers for two sub-types off T-lymphocytes, for the most share (Dendritic concealment S also express train CD8). Relative The abundance off CD4+ and CD8+ T concealments is often used to monitor the progression off year HIV infection.

CD molecules are not merely markers one the concealment surfaces . Not every CD molecule has been thoroughly characterized, important goal most off them bring features to the concealments that curry them. -->

Some important examples

CD1 = a molecule of Complex major of histocompatibility which presents molecules of lipids.
CD2 = a transmembrane protein found in the thymocytes, the cells T, and certain cells NK (natural killer) which acts like ligand for CD58 and CD59 and is implied in the transduction of signal and cellular adherence; expressed in acute lymphoblastic leukemia with cells T and in the lymphoma with cells T.
CD3
CD4
CD5
CD7
CD8
CD9 = Induction of the aggregation of the plates
CD10
CD11c
CD14 = receiving of the LPS (antigen of the suface of the bacteria gram-), interacts with Toll-like Receptor 4 (TLR4), which causes the synthesis and the migration in the core of the factor of transcription NFKB.
CD15
CD20
CD21
CD21
CD23
CD25
CD30
CD31
CD34 Adhesion, found one Hematopoietic precursors (found in high concentrations in umbilical cord blood), Capillary Endothelium, and Embryonic Fibroblasts
CD35
CD36
CD38
CD45
CD56
CD58
CD71 Iron
CD103
CD117 Cellular differentiation, particularly in Hematopoiesis
CD120 Tumor Necrosis Factor, year inflammatory Cytokine
CD142
CD143
CD144 Endothelium. Recent research indicates that CD144 may present Be one summons Leucocytes ace well.
CDw186
CD202a

standard I transmembrane protein found there is thymocytes, T concealments, and nap natural killer concealments that acts ace has ligand for CD58 and CD59 and is involved in signal transduction and concealment adhesion; expressed in T-concealment acute lymphoblastic leukemia and T-concealment lymphoma. --->

the signaling component off the T concealment receptor (TCR) complex--->

Co-receptor for MHCII has; also has receptor used by HIV to enter T concealments-->

CD5
CD7
CD8
CD10
CD11c
CD15
CD20
CD21
CD21
CD23
CD25
CD30
CD31
CD34 Adhesion, found one Hematopoietic precursors (found in high concentrations in umbilical cord blood), Capillary Endothelium, and Embryonic Fibroblasts -->
CD35
CD36
CD38
CD45
CD56
CD58
CD71 Iron
CD103
CD117 Cellular differentiation, particularly in Hematopoiesis
CD120 Tumor Necrosis Factor, year inflammatory Cytokine
CD142
CD143
CD144 Endothelium. Recent research indicates that CD144 may present Be one summons Leucocytes ace well.
CDw186
CD202a

-->

See too

List of human molecules CD

External bonds

HLDA Antibody Database
has list off CD molecules, At ebioscience.com
Another list off CD molecules, At Expasy.org
Yet another list off CD molecules, At PathologyOutlines.com

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