Clozapine
The clozapine is a Antipsychotique derived from the dibenzdiazépine.
Its structure is connected with that of the tricyclic antidepressants nerve sedatives for disorders psychotics (Schizophrénie S) severe in the event of inefficiency of other nerve sedatives.
Good affinity for the D4 receivers, which differentiates it from the others Antipsychotique. In general, less occupation of the receivers D2 and D1, which prevents the pyramidal disorders extra (except with high amounts), and the Dyskinésie late S.
Appreciably improve the negative symptoms of the psychoses and rebellious executives with the others Neuroleptique S. Améliore verbal fluidity, short-term memory and differed and other functions from the frontal lobe.
Present a biodisponibility of 50%, a union with proteins of 95% (attention to the medicamentous interactions of a pharmacokinetic nature), it is very metabolized, and presents a half-life of 6/30h.
Its side effects can be:
- Agranulocytose allergic (80% in the first three months) reversible by stimulation of the colonies granulocytaires.
- of order gastro-intestinal
- Tachycardia by blocking vagal
- incontinence
- hypersalivation
- taken weight.
- deterioration of the electrocardiogram in 25% of the cases, with a potential risks convulsif.
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