Cephalosporine
The cephalosporines are a class of antibiotic ß-lactamines. With the Céphamycine S, they train the sub-group of the Céphem S.
History
Mode of action
The cephalosporines inhibit the development of the bacterial wall, while interfering with the synthesis of the Peptidoglycane or Muréine, by a competitive mechanism of inhibition of the extra-cytoplasmic transpeptidases.
Generations
The core of the cephalosporines can be modified to acquire various properties.GRAM POS. <=======================> GRAM NEG. <= Céphalo 1st gen.=> <= Céphalo 2nd gen =>. <======= Céphalo 3rd gen.======> <========== Céphalo 4th gen.===============>
Cephalosporines of first generation
Escherichia coli , Klebsiella pneumoniae and Proteus mirabilis , goal cuts No activity against Bacteroides fragilis , enterococci, methicilllin-resistant staphylococci, Pseudomonas , Acinetobacter , Enterobacter , indol-positive Proteus gold Serratia . -->- Céfalotine
- Céfapirine
- Céfalexine
- Céfradine
- Céfadroxil
Cephalosporines of second generation
cocci. They resistant are also more to Beta-lactamase. -->-
Céfamandole
- Céfuroxime
- Céfonicid
- Céforanid
- Cefprozil
- Loracarbef
- Céfotétan
- Céfaclor
Cephalosporines of third generation
- Céfotaxime
- Ceftizoxime
- Ceftazidime
- Céfopérazone
- Cefsulodin
- Ceftibuten
- Céfixime
- Céfatamet
- Cefpodoxime
Cephalosporines has wide spectrum
-
Céfépime
- Cefpirome
References
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