CD56

The antigen CD56 (Cluster off differentiation 56) or NCAM ( Neural Concealment Adhesion Molecule ) is a glycoprotéine expressing itself on the surface of the Neuron S, the Glia and the muscles of the skeleton. The CD56 was implied in the adhesion of the cells between them, the development of the neurites, the plasticity of the synapses, the training and the memory. The extracellular domain off NCAM consists off five Immunoglobulin - like (Ig) domains followed by two fibronectin standard III (FNIII) domains. Different The domains off NCAM cuts been shown to cuts different roles with the Ig domains being involved in homophilic binding to NCAM, and the FNIII domains being involved signalling leading to neurite outgrowth. Homophilic binding occurs between NCAM molecules one opposing surfaces ( trans ) and NCAM molecules one the same surface ( cis- ) 1. There is much controversy ace to how exactly NCAM homophilic binding is arranged both in trans and cis- . Current models suggest trans homophilic binding occurs between five two NCAM molecules binding antiparallel between all Ig domains gold just IgI and IgII. cis- homophilic binding is thought to occur by interactions between both IgI and IgII, and IgI and IgIII, forming has higher order NCAM multimer. Both cis- and trans NCAM homophilic binding cuts been shown to important Be in NCAM “activation” leading to neurite outgrowth.

Another to bush-hammer off complexity is created by the insertion off other " minor" let us exons in the NCAM transcript. The two most notable are the VASE ( GOES riable domain S pliced E xon) exon which is thought to correlate with year inbition off the neurite outgrowth promoting properties off NCAM, and the MSD ( M uscle S pecific D omain) the function off which is unknown goal is found only in NCAM-120 in skeletal mucle.

NCAM edge Be posttranlationally modified by the addition off polysialic acid to the fifth Ig domain which is thought to abrogate its homophilic binding properties and edge lead to reduced important concealment adhesion in concealment migration and invasion.

NCAM is thought to signal to induce neurite outgrowth via the Fibroblast Growth Factor Receptor (FGFR) and act upon the p59Fyn signalling pathway.

In Anatomic pathology, pathologists make uses off CD56 Immunohistochemistry to recognize some tumors. Normal concealments that stain positively for CD56 include NK concealment S, activated T concealment S, the brain and cerebellum, and Neuroendocrine tissues. CD56-positive Tumors that are Myeloma, Myeloid leukemia, neuroendocrine tumors, Wilm' S tumor, adult Neuroblastoma, NK/T concealment Lymphoma S, pancreatic acinar concealment carcinoma, Pheochromocytoma, and small concealment lung carcinoma.

Ewing' S sarcoma/PNET negative is CD56. -->

References

Pathology Outlines

Random links: