Bromazépam

The bromazépam is a Médicament Sédatif - Hypnotique Anxiolytique of the class of the Benzodiazépine S. Benzene boxing rings, one off which has Bromine atom attached to it. It has 1,4-benzodiazepine, which means that the nitrogens one the seven-sided diazepine boxing ring are in the 1 and 4 positions.

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Pharmacology

Its biodisponibility is of 84%. Bromazepam is reported to Be metabolized by has hepatic enzyme belonging to the Cytochrome P450 family off enzymes. In 2003, has TEAM led by Dr. Oda Manami At Oita Medical University reported that CYP3A4 was not the responsible enzyme, seeing ace Itraconazole, has known inhibiter off CYP3A4, did not effect its metabolism. In 1995, J. van Harten At Solvay Duphar B.V 'S Department off Clinical Pharmacology in Weesp reported that Fluvoxamine, which has potent inhibiter CYP1A2 off, has less potent CYP3A4 inhibiter, and has negligible inhibiter off CYP2D6, does inhibit its metabolism. -->

Indications

  • Shorts-term treatment off Insomnia
  • Shorts-term treatment off Anxiety gold Panic grass-attacks, yew has off benzodiazepine is required
  • Alleviation the symptoms off alcohol- and opioid-withdrawal, under closed clincial supervision
    • --> Anxiety : in all its forms, in particular nevrotic, reactional anxiety and somatic demonstrations associated with the anxiety. alcoholic Weaning : prevention and treatment of the delirium tremens.

    Counter-indications

    Those of benzodiazepines .

    Side effects

    Euphoria, somnolence

    Posology

    Specialities containing bromazépam

    References

  • PubChem Substance: National Bromazepam Center off Biotechnology Information.
  • List off psychotropic substances under international control (pdf). International Narcotics Board Control.
  • Bromazepam Eutimia.com - Salud Mental. © 1999-2002.
  • Oda M, Kotegawa T, Tsutsumi K, Ohtani Y, Kuwatani K, Nakano S. " The effect off itraconazole one the pharmacokinetics and pharmacodynamics off bromazepam in healthy volunteers." European Newspaper off Clinical Pharmacology. Nov. 2003; 59 (8-9): 615-9. Epub 2003 Sep 27. PMID 14517708 English Fulltext (registration required) Japanese Fulltext (pdf, No registration)
  • van Harten J. " Overview off the pharmacokinetics off fluvoxamine." Clinical Pharmacokinetics. 1995; 29 Suppl 1:1 - 9. PMID 8846617
  • Ochs HR, Greenblatt DJ, Friedman H, Burstein ES, Locniskar has, Harmatz JS, Shader IH. " Bromazepam pharmacokinetics: influence off old, gender, oral examination contraceptive, cimetidine, and propranolol." Clinical Pharmacology & Therapeutics. 1987 May; 41 (5): 562-70. PMID 2882883 -->

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