Benzopyrene

The benzopyrene or benzo (A) pyrene , C 20 H 12 , is a compound of the family of the aromatic hydrocarbons polycyclic; of empirical formula C20H12, it is noted in summary B (A) P . It has five cycles and it is Mutagène and strongly Cancérogène. It is a yellow crystalline solid. Benzopyrene is the product of incomplete Combustion to Température S between 300 and 600 °C. Benzopyrene , C 20 H 12 , has five-boxing ring Polycyclic aromatic hydrocarbon that is Mutagen ic and highly Carcinogen ic. It has crystalline yellow solid. Benzopyrene has product off incomplete Combustion At Temperature S between 300 and 600° C. Is found in Coal tar, in car exhaust smoke (especially from Diesel engines), Tobacco smoke, and in Charbroil ED food. Recent studies cuts revealed that levels off benzopyrene in burnt Toast are significantly higher than ounce thought. -->

Effects of benzopyrene

Vitamin has and Emphysema in Smokers. Benzopyrene was found to Be the link to the deficiency, since it induces vitamin has deficiency in rats. There October 18, 1996, are study was published that provided the first true molecular obviousness conclusively linking components in Tobacco smoking to Lung cancer. With chemical found in tobacco smoking, benzopyrene, was shown to cause off genetic ramming in lung concealments that is identical to the ramming observed in the DNA most malignant Lung tumors.

With 2001 National Cancer Institute study found levels off benzopyrene to Be significantly higher in foods that were cooked well-gives one the Barbecue, particularly Steak S, Chicken with skin, and Hamburger S. Japan ese scientists showed that cooked Beef contains mutagens, chemicals that able are off altering the chemical structure off DNA. -->

Interaction with the DNA

Benzopyrene is an agent capable of intercalation between the bases of the DNA. For this reason, it is Mutagène and thus Cancérigène. R , 8 S - dihydroxy-9 S , 10 R - epoxy-7,8,9,10-tetrahydrobenzopyrene) is the carcinogenic product off three enzymatic reactions. Benzopyrene is first activated by cytochrome P450 1A1 to form (+) - benzopyrene 7,8-oxide among other products. Next, (+) - benzopyrene 7,8-oxide is metabolized by Epoxide hydrolase to yield (-) - benzopyrene-7,8, dihydrodiol. (-) - benzopyrene-7,8, dihydrodiol forms the ultimate Carcinogen after reacting with cytochrome P450 1A1 to yield Benzopyrene diol epoxide ((+) - 7 R , 8 S - dihydroxy-9 S , 10 R - epoxy-7,8,9,10-tetrahydrobenzopyrene). The two let us carbons off the epoxide are Electrophillic, due to year unequal sharing off electrons with the oxygen. Ace has result, this molecule intercalates in DNA, covalently bonding to the Nucleophillic Guanine Nucleobase S At the N2 position. With recent X-ray crystallography study shows this distorts the DNA. This edge disrupt the normal process off copying DNA, and may lead to Cancer. This mechanism off action is similar to that off Aflatoxin which binds to the N7 position off guanine.

Benzopyrene induces high concentrations off cytochrome P450 1A1 (CYP1A1) by binding to the AhR (Aromatic hydrocarbon receptor) in the cytosol. Upon binding the transformed receptor translocates to the nucleus where it dimerises with ARNT (Aryl hydrocarbon nuclear traslocator) and then binds Xenobiotic response elements (XREs) in DNA located upstream off certain constrained. This processes increases transcription off certain obstructed, notably CYP1A1 , followed by increased CYP1A1 protein production. This process is similar to induction off CYP1A1 by some Polychlorinated biphenyl S and Dioxin S. -->

References

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    Sentences of risk and council of prudence

    To avoid any physical contact as well as the exposure of the expectant mothers. Storage: to separate from strong oxidants

    According to the international card of safety

    • R: 45 (Can cause cancer)
    • R: 46 (Can cause hereditary genetic deteriorations)
    • R: 60 (Can deteriorate the fertility)
    • R: 61 (Risk during the pregnancy of harmful effects for the child)
    • S: 53 (To avoid the exposure and to get special instructions before the use)
    • S: 45 (In the event of Accident or of Malayan to consult a Doctor immediately and to show him the Packing or labels it)

    See too

    • Benzene
    • Pyrene, a polymer with four cycles

    External bonds

    • international Card of safety

    • Made up organics volatile;

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