Barbiturate
The barbiturate belong to a family Médicament euse acting like Dépresseur S of the central Nervous system, and whose spectrum of activity extends from the effect Sédatif with the Anesthésie. Some are also used for their virtues anti-convulsivantes. All are derived from the Barbiturate acid. They nowadays are much prescribed because of their side effects, the risk of abuse, and the arrival on the market of Molécule S with the similar effects but without the noxious effects of barbiturates.
Medical use
The use of barbiturates is limited today to some products anticonvulsivants and like inductors of the general Anesthésie. The existing molecules are (by Name international non-proprietary = DCI):
-
Amobarbital (Hypnotic)
- Aprobarbital (Hypnotic)
- Barbital
- Butabarbital (Hypnotic)
- Butalbital (Sedative)
- Hexobarbital (Hypnotic/Anesthetic)
- Méphobarbital (Anxiolytique)
- Pentobarbital (Hypnotic)
- Phenobarbital (Anticonvulsivant)
- Sécobarbital (Hypnotic)
- Talbutal (Hypnotic)
- Thiobarbital (Anesthetic)
Barbiturate abuse
The use of barbiturates was very widespread in first half of the 20th century.
With moderated amount, these drugs involve an effect very close to that produced by the alcoholic Intoxication (Ivresse). The principal Symptôme S are a loss of driving coordination, an incoherent speech, disorders of the judgment. These effects (and too often) were sometimes required from an entertaining or sedative point of view.
In the case of a chronic abuse very quickly develops a tolerance with barbiturates, a dependence physical and psychological. The tolerance in particular involves a contracting of the zone ranging between the amount necessary to obtain the required effect and the amount mortal, by progressive increase in the amount necessary to obtain the same effect. At a certain point, the necessary amount becomes higher than the lethal amount, involving Coma and death without urgent medical assumption of responsibility.
Historically, and although the majority of the patients drew benefit from barbiturates, the prevalence of the Toxicomanie S, the accidents of weaning ( Convulsion S sometimes mortals) and of the accidents of Intoxication due to a barbiturate excess conduirent medicamentous industry with the development of alternative therapies (in particular the Benzodiazépine S ) which strongly restricted the use of barbiturates.
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