The apiole (of Latin celery , the parsley) is a generic name given to some Ester S extracted the Persil, Aneth or Fenouil. It is the active ingredient of parsley seeds.
Heinrich Christoph Link, pharmacist of Leipzig, discovered the substance in 1715, in the form of greenish crystals, by extraction in vapor phase of essential parsley oils.
ChemistryThe generic formula of these compounds is C6H (O-CH3) 2 (O 2CH 2) C3H5.
The apiole is a term which can indicate two made up:
- the apiole of parsley, extract of the parsley seeds, is an ether oxidizes derived from the allyl apionol, flux with 30°, boiling with 294°. Isoapiol differs from the apiole of parsley by the replacement of the allyl group by the propenyl group. One obtains it by action of potash in boiling on the apiole.
- the apiole of dill meets in the gasolines of Aneth and Fenouil. It differs from the apiole of parsley by the position of an ethyl oxide group. The action of potash also transforms it into isoapiol.
Pharmaceutical useThe apiole is used (in the form of essential oil, or in pure form) like Antipériodique, Emménagogue and Fébrifuge. It is used in amounts from 0.2 to 0.6 ml.
It is irritating, suspecté to be toxic with strong amount, damaging the liver and the kidneys. It causes faintnesses with strong amount (nauseas, ringing in the ears, giddinesses), an headache).
Hippocrates mentioned already parsley like bleaches on grass abortive, and the plant was used to this end until the Moyen-âge. This property is due to the apiole: it is abortive relatively sure taken in minor amount.
In 1855 Joret and Homollé discovered that it was an effective cure against the lack of Menstruation and to look after the Aménorrhée S
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