Anticipation (Genetic)
The anticipation in genetics is a term used to describe the fact that some genetic diseases worsen or can progressively worsen in a family transmission of this disease during the generations.
Sometimes the disease worsens only if it east transmitted by the mother one then speaks about maternal anticipation or by the father one then speaks about paternal anticipation .
This phenomenon is found in almost all the genetic diseases whose pathological change is a Expansion or repetition of a Codon.
If the normal length of the repetition lies between the normal length and the length involving an expression of the genetic disease, one speaks about premutation . This premutation can sometimes in a number weak case involve the disease.
The existence of these genetic diseases with anticipation returns the genetic Conseil very delicate.
Some examples of genetic disease to anticipation:
- Disease of Huntington
- myotonic Dystrophy of Steinert (most frequent of the myopathies in France)
- Syndrome of X fragile (First hereditary cause of delay in France)
Sources
| Random links: | Verneuil-large | Neil McLeod | Nuremberg | Apigénine | Samsara (group) | Note_de_Kessai |