Analgesic

The analgesics are drugs used in Médecine having for goal to eliminate the pain from a patient (the Antalgiques doing nothing but attenuate the pain).

The same subject can need or not analgesic, for the same intervention, according to the circumstances. This is usually observed by the doctors operating in zone of conflict. In the intense stress of the battle field, the death threat, the quantity of Endorphine S generated by the brain involves a autoanalgesy which can be sufficient for rather important operations. The surgeons of ground do not have besides the choice, they often miss requirements with the implementation of analgesics.

Classes of analgesics

Morphine central analgesics

They are here the Morphine and all its derivatives, more or less powerful according to the molecules. They can be used by way intravenous (IV), subcutaneous (SC), intramuscular (IM), transdermic (patch), oral way (PO = per bone).

These drugs belong to most powerful currently known but are not stripped of side effects (for example, the respiratory Détresse (Apnée), the nausea S and Vomissement S, the Constipation, the Retention of urine,…) and are unfortunately not always sufficiently effective on certain pains.

All these drugs are not equivalent between them and certain associations are contra-indicated under penalty of seeing to cancel the effects of each drug (antagonistic effect).

Examples:

Certain molecules are very quickly effective (20 seconds) but for very little time (1 to 2 minutes): it is the case of the rémifentanil. Other molecules act more slowly (15 minutes) but during longer (3 to 4 a.m.): it is the case of morphine. Thus, these molecules will not be employed in the same circumstances.

Nonmorphine central analgesics

One currently finds in this class 4 molecules:
  • the Dextropropoxyphène

  • the Tramadol
  • the Néfopam

The 3 first available only or are associated with other antalgic molecules. They can be used by way IV, IM or PO.

Peripheral analgesics

One finds here:
  • the Paracetamol or Acétaminophène.

  • the anti-inflammatory drugs not stéroïdiens (AINS), among which the aspirine.

They are generally used by way IV, IM, PO or intra-rectal.

Other drugs analgesics

The molecules present in this group were not developed for their action analgesic but it is with use that one could realize of this effect.

One finds thus in this group:

  • the Antidepressant S, of which the analgesic effect occurs before the antidepressant effect.

  • the Neuroleptique S, which also have an effect Anxiolytique.
  • the Benzodiazépine S, which also have effects anxiolytic, Myorelaxant S, amnésiants, Sédatif S and Hypnotique S.
  • the Antiépileptique S have an interest in the pains of neurological origin.
  • the corticosteroids, of which the analgesic effect passes by an action anti-inflammatory drug.
  • the Calcitonine, used in the osseous pains.
  • MEOPA Mixture Equimolaire Oxygen-Protoxide of Nitrogen in the assumption of responsibility of the caused pains

The antispasmodiques ones

They are used in the visceral pains of the digestive, urinary and gynaecological tracts. One finds here:
  • the Trimébutine

  • the Phloroglucinol
  • the Mébévérine,…

The routes of administration are the same ones as the peripheral analgesics.

Attention: To always ask council your doctor before taking a treatment.

Safety

Simple: Analgesic

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