Amide

A amide is a Composé organics derived from a carboxylic acid. An amide has a nitrogen atom dependant on its grouping Carbonyle. The amides can be primary, secondary or tertiary, according to the number of hydrogen atoms related to nitrogen. The amides are an important group in the chemistry of proteins, because they are partly responsible for the peptide connection between the various amino-acids.

Example of amide:

NR - methyl acetamide (CASE 79-16-3)

There exist Polyamide S, which are polymers comprising the function amide. Nylon (R) for example is polyamide 6,6; polyamide 11 when with him, has as a trade name Rilsan (R). The figure indicated corresponds to the number of carbon atoms on the polyamide chain between two functions amides.

The connection between the amino-acids, to form proteins, is a bond amide.

Synthesis

  • starting from Carboxylic acid activated and of a amine, such as for example
    • chloride acid hydrochloric acid R-CO-Cl and release HCl, trapped by the amine

      hydrochloric acid HCl produced perhaps neutralized by the amine but also by the addition of a sensor of proton like the Pyridine for example.

    • Anhydride of acid R-CO-O-CO-R and release of carboxylic acid, neutralized by the amine

      the produced acid is not enough reactive to form an amide with the amine.

    • Carboxylic acid activated by a reactive of peptide coupling

Conversion of amides

The amides are not very reactive compounds. They can be not easily hydrolized to regenerate the carboxylic acid and the amine. It is also possible to reduce them using Aluminohydrure of lithium to generate a substituted amine.

Random links:Rigoberta Menchú | Bradia | Della Magliana bandaged | Large island of Ratones | The Choice of Selma