Acid dichloroacetic

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The acid of dichloroacetic (acid dichloroéthanoïque, systematic name) to the structure of the acetic Acid for which one would have substituted two of the three atoms of Hydrogène of the methyl group by atoms of Chlore. It is prepared by the reduction of trichloracetic acid.

Chemistry

The dichloroacetic chemistry of the acid is closely related to that of the halogenous organic acids. It is a family member of the chloroacetic acid . The ion dichloroacétate is produced as of dissolution in water. It is about a strong acid with a pKa of 1,3, and which is very corrosive and extremely destructor of fabrics of the mucous membranes and the higher respiratory tracts.

Therapeutic use

Lactic acidosis

The ion dichloroacétate stimulates the activity of the enzyme Pyruvate déshydrogénase by inhibiting the enzyme kinase of déshydrogénase of pyruvate. Thus, it decreases the production of Lactate by shifting the metabolism of the Pyruvate of Glycolyse towards oxidation in the Mitochondrie S. This property was employed to treat the Lactic acidosis at the human ones.

Cancer

In recent experiments with the University of Alberta, the dichloroacétate was also used to regulate and reconstitute normal metabolic functions in mitochondries deadened by cancer. This is particularly interesting in the cancerous cells , which are not destroyed by they-even (Apoptose) due to the damaged metabolic functions. Tiny amounts of dichloroacétate reduced breast cancers, cerebral tumors, and lung cancers on human cells and in the rat. Although this indicates that the acid dichloroacétiquee could be in the long term employed in human therapy against cancer, no clinical test was carried out on patients.

Side effects

The therapeutic use of the dichloroacétate can cause pains, numbnesses and disturb walk.

The dichloroacétate can also have effects Anxiolytique S or Sédatif S.

References

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