454 Life Sciences

Society based with Branford (Connecticut) with the the United States, specialized in the manufacture of Sequencer of genes to high banc.

It is the company which launched out in the project of sequencing of the genome of the Homme of Néandertal, in collaboration with the the Max Planck Institute.

Technique

The technique employed is a kind of sequencing in Real-time. During the synthesis of a new bit of DNA, there is reading of the fluorescence brought by new nucleotide.

Products

The company produces GS 20 (initials meaning " Genome Sequencer 20 mégabases") capable of séquencer until 20 Mégabases by cycle of measurement (run) of 4-5 hours.

The technique used allows séquencer of great quantities of DNA lower costs in comparison with the methods of Sanger. The sequences rich in GC are not more one problem, nor the impossibility of cloner certain fragments.

Moreover, the technique is able to detect changes in a pool of amplicon on a level of very low sensitivity, which can have implications in clinical research, in particular in research against cancer or the HIV.

External bond

Official site of 454 Life Sciences

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